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Plos One : the Effects of Amino Acid Composition of Glutamine- Rich Domains on Amyloid Formation and Fragmentation, Volume 7

By Baskakov, Ilia, V.

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Book Id: WPLBN0003960974
Format Type: PDF eBook :
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Reproduction Date: 2015

Title: Plos One : the Effects of Amino Acid Composition of Glutamine- Rich Domains on Amyloid Formation and Fragmentation, Volume 7  
Author: Baskakov, Ilia, V.
Volume: Volume 7
Language: English
Subject: Journals, Science, Medical Science
Collections: Periodicals: Journal and Magazine Collection (Contemporary)
Historic
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Publisher: Plos

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Baskakov, I. V. (n.d.). Plos One : the Effects of Amino Acid Composition of Glutamine- Rich Domains on Amyloid Formation and Fragmentation, Volume 7. Retrieved from http://worldebooklibrary.com/


Description
Description : Fragmentation of amyloid polymers by the chaperone Hsp104 allows them to propagate as prions in yeast. The factors which determine the frequency of fragmentation are unclear, though it is often presumed to depend on the physical strength of prion polymers. Proteins with long polyglutamine stretches represent a tractable model for revealing sequence elements required for polymer fragmentation in yeast, since they form poorly fragmented amyloids. Here we show that interspersion of polyglutamine stretches with various amino acid residues differentially affects the in vivo formation and fragmentation of the respective amyloids. Aromatic residues tyrosine, tryptophan and phenylalanine strongly stimulated polymer fragmentation, leading to the appearance of oligomers as small as dimers. Alanine, methionine, cysteine, serine, threonine and histidine also enhanced fragmentation, while charged residues, proline, glycine and leucine inhibited polymerization. Our data indicate that fragmentation frequency primarily depends on the recognition of fragmentationpromoting residues by Hsp104 and/or its co-chaperones, rather than on the physical stability of polymers. This suggests that differential exposure of such residues to chaperones defines prion variant-specific differences in polymer fragmentation efficiency

 

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