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Effects of Phthalic Acid Esters (Paes) on the Neonate and Aspects of Teratogenic Actions

By Thomas, John A.

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Book Id: WPLBN0000679764
Format Type: PDF eBook
File Size: 401,163 KB.
Reproduction Date: 2005

Title: Effects of Phthalic Acid Esters (Paes) on the Neonate and Aspects of Teratogenic Actions  
Author: Thomas, John A.
Language: English
Subject: Government publications, United Nations., United Nations. Office for Disarmament Affairs
Collections: Disarmament Documents
Publication Date:
Publisher: United Nations - Office for Disarmament Affairs (UNODA)


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Thomas, J. A. (n.d.). Effects of Phthalic Acid Esters (Paes) on the Neonate and Aspects of Teratogenic Actions. Retrieved from

Government Reference Publication

Excerpt: During the past few years there have been a number of review articles pertaining to the biologic effects of the phthalic acid esters (PAE) (1-3). In 1981, the National Toxicology Program and the U.S. Interagency Regulatory Liaison Group sponsored a Conference on Phthalates. A host of U.S. governmental bioassays and reports pertaining to the biologic and possibly the carcinogenic actions of some of the phthalates have been cited (4). In many respects this International Conference on the Phthalic Acid esters is an outgrowth of early conferences and the continuing research interests in assessing the biological effects of these chemicals. Several laboratories around the world continue to explore the action(s) of the phthalates on a number of physiologic systems. There is very little information about the effects of these chemicals upon the neonate or upon the young. Some information is, however, available as to the possible teratogenic actions of certain of the phthalate. Some phthalates appear to be more fetotoxic or embryotoxic than others. Generally, there also appear to be age-related differences with respect to PAE-induced toxicity, but no studies have focused specifically upon the effects of these plasticizers on the neonate. Of the large number of commercially available PAE, diethylhexyl phthalate (DEHP) seems to have received the most scientific or toxicologic investigation.


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