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Uncouplers of Oxidative Phosphorylation

By Terada, Hiroshi

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Book Id: WPLBN0000679744
Format Type: PDF eBook
File Size: 400,991 KB.
Reproduction Date: 2005

Title: Uncouplers of Oxidative Phosphorylation  
Author: Terada, Hiroshi
Language: English
Subject: Government publications, United Nations., United Nations. Office for Disarmament Affairs
Collections: Disarmament Documents
Publication Date:
Publisher: United Nations - Office for Disarmament Affairs (UNODA)


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Terada, H. (n.d.). Uncouplers of Oxidative Phosphorylation. Retrieved from

Government Reference Publication

Excerpt: The common bioenergy currency, ATP, is synthesized in energy-transducing membranes such as those of mitochondria, chloroplasts, and various microorganisms. The energy to drive the uphill reaction (phosphorylation) for synthesis of ATP from Pi (orthophosphate) and ADP by ATP synthase (ATPase) is supplied by sequential oxidation-reduction chain reactions in electron transporting systems. During photophosphorylation in chloroplasts, this energy is supplied by the photosynthetic electron transport chain, whereas during oxidative phosphorylation in mitochondria and prokaryotic cells, it is supplied by the respiratory chain. Thus ATP is synthesized by coupling two reactions, electron transport and phosphorylation. Uncouplers inhibit ATP synthesis by preventing this coupling reaction in such a fashion that the energy produced by redox reactions cannot be used for phosphorylation. Thus, in the presence of an uncoupler, the activities of electron flow and ATPase are not inhibited, but ATP synthesis cannot take place (Fig. 1) (1).


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