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World Health Organization : Year 2003 ; World Health Organization, Biological Standardization, No. 03.1961: Report Op an International Collaborative Study to Evaluate a World Health Organization HIV-1 RNA Genotype Reference Panel

By H. C. Holmes

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Book Id: WPLBN0000224078
Format Type: PDF eBook
File Size: 0.9 MB
Reproduction Date: 2005
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Title: World Health Organization : Year 2003 ; World Health Organization, Biological Standardization, No. 03.1961: Report Op an International Collaborative Study to Evaluate a World Health Organization HIV-1 RNA Genotype Reference Panel  
Author: H. C. Holmes
Volume:
Language: English
Subject: Health., Public health, Wellness programs
Collections: Medical Library Collection, World Health Collection
Historic
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Publisher: World Health Organization

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Holmes, H. C. (n.d.). World Health Organization : Year 2003 ; World Health Organization, Biological Standardization, No. 03.1961. Retrieved from http://worldebooklibrary.com/


Description
Medical Reference Publication

Excerpt
Summary Twenty-eight laboratories fiom 16 corntries participated in a collaborative study to evaluate an HIV-1 RNA Genotype Reference Panel (NLBSC Code 011466) for use with nucleic acid-based tests (NAT). The Reference Panel consisted of 11 coded samples representing different HIV-1 genotypes (subtypes A, B, C, D, AE, F, G, AG-GH, groups N and 0) as well as a negative diluent control. Each laboratory assayed the eleven panel members concurrently with the la International Standard for HIV-1 RNA (NIBSC Code 97/656) on at least three separate occasions and the data collated and analysed at NIBSC. Twenty-nine sets of data were received, 19 fiom quantitative and 10 hm qualitative assays, with six different commercial assays and five in-house assays represented. The results showed that subtypes A-E were detected consistently by most assays, although there were minor discrepancies between assays. However, a variety of problems occurred with the detection and quantitation of the other subtypes and groups. In particular the Nuclisens assay had difficulty in the detection of subtypes F, G, AG-GH and group N. Most assays failed to detect the group O representative. The study highlighted the shortcomings of some molecular assays particularly in detection of some of the non-B genotypes, which are important vinises in the global AIDS pandernic and illustrated the value of a well-characterized genotype panel. It was proposed that the HIV-1 RNA Genotype Reference Panel be established as a WHO Reference Reagent.

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