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Applications of Nmr in Drug Discovery

By Roberts, Gordon C. K.

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Book Id: WPLBN0000158033
Format Type: PDF eBook
File Size: 0.8 MB
Reproduction Date: 2005
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Title: Applications of Nmr in Drug Discovery  
Author: Roberts, Gordon C. K.
Volume:
Language: English
Subject: Health., Medical research, Medical reports
Collections: Medical Library Collection
Historic
Publication Date:
Publisher: Centers for Disease Control and Prevention

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K. Robert, G. C. (n.d.). Applications of Nmr in Drug Discovery. Retrieved from http://worldebooklibrary.com/


Excerpt
In the half-century since its discovery, nuclear magnetic resonance (NMR) has become the single most powerful form of spectroscopy in both chemistry and structural biology. The dramatic technical advances over the past 10–15 years, which continue apace, have markedly increased the range of applications for NMR in the study of protein–ligand interactions. These form the basis for its most exciting uses in the drug discovery process, which range from the simple identification of whether a compound (or a component of a mixture) binds to a given protein, through to the determination of the full three-dimensional structure of the complex, with all the information this yields for structure-based drug design.

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