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Genotoxicity of N-Acetylarylamines in the Salmonellalhepatocyte System

By Thorgeirsson, Snorri S.

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Book Id: WPLBN0000001348
Format Type: PDF eBook
File Size: 0.2 MB
Reproduction Date: 2005

Title: Genotoxicity of N-Acetylarylamines in the Salmonellalhepatocyte System  
Author: Thorgeirsson, Snorri S.
Language: English
Subject: Government publications, United Nations., United Nations. Office for Disarmament Affairs
Collections: Government Library Collection, Disarmament Documents
Publication Date:
Publisher: United Nations- Office for Disarmament Affairs (Unoda)


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Thorgeirsson, S. S. (n.d.). Genotoxicity of N-Acetylarylamines in the Salmonellalhepatocyte System. Retrieved from

Government Reference Publication

Excerpt: Carcinogenic N-acetylarylamines, such as &acetylaminofluorene (AAF), are extensively metab* lized in animals that are both resistant and susceptible to the carcinogenic effects of these compounds U). In the organism, metabolic processing of N-acetylarylamines involves both detoxification and activation (toxification), and there is convincing evidence that the ratio between these two processes may, to a large extent, determine the susceptibility to carcinogenesis from these compounds (2, 3). Recent studies on the mechanism of AAF-induced hepatocarcinogenesis have clearly established that the oncogenic process proceeds via initiation and promotion phases (4). AAF is a complete rat liver carcinogen that can provoke initiation as well as maintain the promotional aspects of the carein* genic process in this species. It thus seems reason-.


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